October 28, 2016

False positives

Before a medical diagnostic test is introduced, it is supposed to be evaluated carefully for accuracy. In particular, if the test is going to be used on the whole population, it’s important to know the false positive rate: of the people who test positive, what proportion really have a problem?  Part of  this process is to make sure that the test works as a biological or chemical assay: is it accurately measuring, say, carbon monoxide or glucose in the blood.  But that’s only part of the process.  You also need to worry about what threshold to use — how high is ‘high’ — and whether people could have high carbon monoxide levels without being smokers, or high glucose levels without being diabetic.

I haven’t heard any suggestion that the tests for methamphetamine contamination in houses fail the first step. There’s meth present when they find it. But Housing NZ were treating the high assay value as evidence that (a) the house was dangerous to live in, and (b) that the tenant was responsible. The false positive rates for (a) and (b) were not established, and appear to be shockingly high given the consequences.

The Ministry of Health has now released new guidelines on meth contamination, with concentration thresholds based on evidence (though towards the low end of what their evidence would support).  They claim to have repeatedly warned Housing NZ. Russell Brown has an excellent summary of the situation at Public Address.

While this is all a step forward, it’s not addressing the question of (b) above: if there’s methamphetamine present at above the new action threshold, it appears that this is still going to be taken as evidence of the tenant’s culpability. That would only make sense if, contrary to the advertising from the meth-testing companies, low-level meth contamination were very rare in rented NZ houses.

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Thomas Lumley (@tslumley) is Professor of Biostatistics at the University of Auckland. His research interests include semiparametric models, survey sampling, statistical computing, foundations of statistics, and whatever methodological problems his medical collaborators come up with. He also blogs at Biased and Inefficient See all posts by Thomas Lumley »

Comments

  • avatar
    Marcus Hayes sr

    I tested positive for methamphetamines,when I don’t take or use any drugs at all,not even over the counter does anyone know of good or drink that could cause this?

    7 years ago