Posts written by Thomas Lumley (1302)

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Thomas Lumley (@tslumley) is Professor of Biostatistics at the University of Auckland. His research interests include semiparametric models, survey sampling, statistical computing, foundations of statistics, and whatever methodological problems his medical collaborators come up with. He also blogs at Biased and Inefficient

October 30, 2014

Cocoa puff

Both Stuff and the Herald have stories about the recent cocoa flavanols research (the Herald got theirs from the Independent).

Stuff’s story starts out

Remember to eat chocolate because it might just save your memory. This is the message of a new study, by Columbia University Medical Centre.

 

Sixteen paragraphs later, though, it turns out this isn’t the message

“The supplement used in this study was specially formulated from cocoa beans, so people shouldn’t take this as a sign to stock up on chocolate bars,” said Dr Simon Ridley, Head of Research at Alzheimer’s Research UK.

 

There’s a lot of variation in flavanol concentrations even in dark chocolate, but 900mg of flavanols would be somewhere between 150g and 1kg of dark chocolate per day.  Ordinary cocoa powder is also not going to provide 900mg at any reasonable consumption level.

The Herald story is much less over the top. They also quote in more detail the cautious expert comments and give less space to the positive ones. For example, that the study was very small and very short, and the improvement in memory was just in one measure of speed of very-short-term recall from a visual prompt, or that this measure was chosen because they expected it to be affected by cocoa rather than because of its relevance to everyday life. There was another memory test in the study, arguably a more relevant one, which was not expected to improve and didn’t.

Neither story mentions that the randomised trial also evaluated an exercise program that the researchers expected to be effective but wasn’t. Taking that into account, the statistical evidence for the effect of flavanols is not all that strong.

October 29, 2014

Briefly

  • The Herald reports on a genetic study in Finland that found a couple of rare genetic variants which were about 2.5 times more common in people who had committed multiple violent crimes.  I don’t have anything criticise about the story, just a point about genetics. When you’re trying to interpret an association like this one from a philosophical or policy point of view, it’s helpful to note that roughly 95% of their extremely violent criminals carried a genetic variant present in only 50% of the population — an odds ratio more like 25 than 2.5.
  • A story and interactive tool at Fusion, showing how changes in youth turnout would affect the US election results next week (if they happened, which they probably won’t).
  • From Anthony Tockar at Neustar, how anonymised taxi ride data from New York could be used to track passengers, not just drivers.
  • And the same taxi data being used for good, via mathbabe.org
October 28, 2014

Absolute, relative, correlation, cause

The conclusions of a recent research paper

Delivery by [caesarean section] is associated with a modest increased odds of [autism], and possibly ADHD, when compared to vaginal delivery. Although the effect may be due to residual confounding, the current and accelerating rate of[caesarean section] implies that even a small increase in the odds of disorders, such as [autism] or ADHD, may have a large impact on the society as a whole. This warrants further investigation.

The Herald

Babies born through Caesarean section are more likely to develop autism, a new study says.

Academics warn the increasingly popular C-section deliveries heighten the risk of the disorder by 23 per cent.

There’s a fairly clear difference in language: the news story is fairly clearly implying that caesarean sections cause autism; the research paper is being scrupulously careful not to say that.

Using a relative risk is convenient in technical communication, but in non-technical communication makes the impact seem greater than it really is. The US Centers for Disease Control estimate a risk of 1 in 68 for autism spectrum disorder (there aren’t systematic NZ data).  If the correlation with C-section really is causal, we’re talking about roughly 14 kids with autism spectrum disorders per 1000 without a C-section and about 17 per 1000 with a C-section. The absolute risk increase, if it’s real, is about 3 cases per 1000 C-sections.

It’s also important to be clear that this correlation cannot explain much of the recent increases in autism. A relative risk of 1.23 means that if we went from no C-sections to 100% C-sections there would be a 23% increase in autism spectrum disorder. The observed increase is about five times that, and since  C-sections have only increased about 10 percentage points, not 100 percentage points, the observed increase in autism is about 50 times what this correlation could explain.

There are (I’m told by people who know the issues) good reasons to think there are too many C-sections.  This probably won’t be one of the most important ones.

 

October 24, 2014

Something in the air

There’s a story “Pollution can cause lung problems in unborn baby – research” in the Herald, which I’m not  convinced by, but the reasons are relatively subtle.

The researchers compared levels of traffic-related air pollution exposure for different pregnant women, and looked at the lung function of the children at age four and a half (press release).  The story gets the name of the main pollutant (nitrogen dioxide) wrong in two different ways, but is otherwise a good summary.  It’s all correlation, but weaker associations than this are fairly reliably estimated for short-term exposures to air pollution. Long-term exposure is different, and that’s what’s interesting.

Studies of short-term effects of air pollution compare the number of people dying or going to hospital on days when pollution is high to the number on days where pollution is low.  That is, the comparisons of pollution are for the same people and for the same air pollution monitors. There are a fairly limited selection of other factors that could explain the association — the main ones being related to weather.

Studies of longer-term effects compare people with high exposure to pollution and people with low exposure to pollution.  Actually, they don’t quite do that, because air pollution monitoring is expensive in labour and equipment. They compare people with high estimated exposure and low estimated exposure. Since we’re comparing different people, any factor that affects health and also affects where people live could cause a bias, and it’s very well established that poorer people tend to get exposed to more pollution, at least in cities. Also, since we’re comparing different air pollution monitors, there can be biases from how representative the monitors are of the local area.

These problems mean that it’s much harder to be confident about effects of longer-term air pollution exposure, even though these effects are likely to be bigger than the short-term ones. Fortunately, we don’t need to be sure of these effects in setting public policy. The main source of the pollution is traffic, and there are other independent reasons why we want to have fewer cars burning less fuel.

On the statistical generalisability of personal experience

Going by people I know in real life or on Twitter, you would think the majority of people brought up in the Mormon church become scientists. though I am informed this is not actually the case.

There’s an interview with one of them, Heather Hendrickson, in the Herald.

October 23, 2014

Official Information and Open Data

In recent years it has become much easier to just go and get routine government data. It’s now easy to put data up online, and organisations do it. We might whinge about how often the URLs and layouts change, but you can get and reuse information in ways that used to be impossible. For examples in just one field, see the blog of the NZ geodata company Koordinates.

On the other hand, non-routine requests seem to be increasingly difficult. David Fisher, of the Herald, gave a talk in Wellington last week on the Official Information Act. The talk has been published at Public Address

When I started, if I wanted to know about something, I would ring and ask. For example, if I want to know about how Kauri stumps were exported, I would ring up the equivalent of the MPI and ask how Kauri stumps get exported. I would then spend half an hour on the phone to the guy who oversaw the exporting – often the guy who was physically down at the docks – and I would be informed.

It seems a novel idea now. I can barely convey to you now what a wonderful feeling that is, to be a man with a question the public wants answering connecting with the public servant who has the information.

Things have changed, he says.

October 22, 2014

Screening the elderly

I’ve seen two proposals recently for population screening of older people. They’re probably both not good ideas, but for different reasons.

We had a Stat of the Week nomination for a proposal to screen people over 65 for depression at ordinary GP visits, to prevent suicide. The proposal was based on the fact that 70% of the suicides were in people who had visited a GP within the past month.  If the average person over 65 visits a GP less than about 8.5 times a year, this means those visiting their GP are at higher risk.  However, the risk is still very small: 225 over 5.5 years is 41/year, 70% of that is 29/year.

To identify those 29, it would be necessary to administer the screening question to a lot of people, at least hundreds of thousands. That in itself is costly; more importantly, since the questionnaire will not be perfectly accurate there will be  tens of thousands of positive results. For example, a US randomised trial of depression screening in people over 60 recruited 600 participants from 9000 people screened. In the ‘usual care’ half of the trial there were 3 completed suicides over the next two years; in those receiving more intensive and focused help with depression there were 2. The trial suggests that screening and intensive intervention does help with symptoms of major depression (probably at substantial cost), but it’s not likely to be a feasible intervention to prevent suicide.

 

The other proposal is from the UK, where GPs will be financially rewarded for dementia diagnoses. In contrast to depression, dementia is pretty much untreatable. There’s nothing that modifies the course of the disease, and even the symptomatic treatments are of very marginal benefit.

The rationale for the proposal is that early diagnosis gives patients and their families more time to think about options and strategies. That could be of some benefit, at least in the subset of people with dementia who are able and willing to talk about it, but similar advance planning could be done — and perhaps better — without waiting for a diagnosis.

Diagnosis isn’t like treatment. As a British GP and blogger, Martin Brunet, points out

We are used to being paid for things of course, like asthma reviews and statin prescribing, and we are well aware of the problems this causes – but at least patients can opt out if they don’t like it.

They can refuse to attend a review, decline our offer of a statin or politely take the pill packet and store it unopened in the kitchen cupboard. They cannot opt out of a diagnosis.

 

Infographic of the week

From the twitter of the Financial Times, “Interactive: who is the better goalscorer, Messi or Ronaldo?”

I assume on the FT site this actually is interactive, but since they have the world’s most effective paywall, I can’t really tell.

The distortion makes the bar graph harder to read, but it doesn’t matter much since the data are all there as numbers: the graph doesn’t play any important role in conveying the information. What’s strange is that the bent graph doesn’t really resemble any feature of a football pitch, which I  would have thought would be the point of distorting it.

B0cvaNfIEAA0WZH

 

The question of who has the highest-scoring season is fairly easy to read off, but the question of “who is the better goalscorer” is a bit more difficult. Based on the data here, you’d have to say it was too close to call, but presumably there’s other information that goes into putting Messi at the top of the ‘transfer value’ list at the site where the FT got the data.

(via @economissive)

October 20, 2014

Advertising about your weekend

Today’s Daily Mail story in the Herald is unusual, not because it’s a survey done to advertise a company, but because the company of that name in New Zealand is getting a freebie. The story is describes people lying about their boring weekends, and it’s a survey commissioned by Travelodge, the UK budget hotel chain. The hotel company with with the Travelodge brand in this part of the world is, as far as I can tell, not related.

What is notable about the story, which confused me at first when looking across multiple versions in the British media, is that it’s a re-run. Travelodge did the same survey in 2011, on a larger sample. Here’s the Mail story from last time; the Herald escaped it then.

The press release for this year’s survey isn’t up, but if it’s like the 2011 one it won’t give any information about how the survey was conducted, and only reports a few highlights of the results, so if it were about anything important you wouldn’t want to pay attention.

October 19, 2014

Broadening your data display palate — multivariate beer?

Nathan Yau at Flowing Data has a project page on multivariate beer. That is, he wants to use beer recipes to encode information about US counties taken from the American Community Survey:

The great thing about beer is that it has plenty of dimensions to work with: body, bitterness, head retention, hop profile, color, aroma, alcohol by volume, and plenty more. The amount of various ingredients affects how beer looks, tastes, and smells.

Still a work in progress, here’s how a beer recipe is formed.

  • Greater head retention should increase with higher education, so a grain called Carapils is added.More hop aroma represents higher employment. This comes from more hops at the end of a boil and dry hopping.
  • Rye adds spice and complexity to the beer as health care coverage increases.
  • A darker-colored and more full-bodied beer comes from higher median household income and Crystal Malt 40.
  • More hop bitterness and flavor means more people per square mile, and the type of hops — Cascade, Centennial, Citra, Warrior, and Magnum — represents the races of the population.

That sounds fun, but I’m not convinced by its possibilities for data communication.

People often want to use other senses than vision for data communication, because they would provide more dimensions.  There are a couple of problems with this. First, the bandwidth and resolution of the other senses aren’t as good — for example, even a professional tea-taster can’t manage much over a thousand data points per day. Second, there’s encoding: the idea is to take advantage of the richness of experience from using all the senses, but it’s hard enough to work out how to encode numbers visually, and it will be much harder to come up with encodings for the other senses that convey accurate quantitative information.